If you are yet to try a multiplayer game in Civilization 5, this guide will give you all the information you need on setting one up and interacting with real-life opponents! Joining a Civilization 5 Multiplayer Game Playing NPCs is one thing – and in unpatched versions of the game it might described as another thing entirely – but there is nothing like the experience of playing someone with the same lust for conquest and scientific advances as you. Whether you have played every version of Civilization (including the spin-offs) since 1991 or you just got into the game series with Civilization 5, you haven’t truly enjoyed the game until you have tried multiplayer mode!